NATURAL FACTORS - SAMe - 60 Tablet(s) - NPN: 80004055 -- Clinical research shows that SAMe elevates mood and has a positive effect on behaviour. It also maintains cartilage health and contributes to the production of joint-supporting compounds such as glucosamine and chondroitin. SAMe works actively with folic acid and vitamin B12, and together can promote healthy brain functioning. Natural Factors SAMe is specially coated for ease of swallowing and maximum bioavailability, which also enhances SAMe's stability. Individuals who are using prescription antidepressants or who suffer from bipolar disorder should use this product only under the supervision of a health care practitioner.